Recent applications of seven-membered rings in drug design

Gilles Ouvry

doi:10.1016/j.bmc.2022.116650

Recent applications of seven-membered rings in drug design

Bioorg Med Chem. 2022 Mar 1:57:116650. doi: 10.1016/j.bmc.2022.116650. Epub 2022 Jan 31.

Author

Gilles Ouvry¹

Affiliation

¹ Evotec (U.K.) Ltd., 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ, UK.

PMID: 35123178
DOI: 10.1016/j.bmc.2022.116650

Abstract

This short review aims at highlighting recent design strategies hinged on using seven-membered rings. Analyses of the different selected examples coupled with torsion profiles derived from the CCDC suggest some of these strategies could have broad applications.

Publication types

Review

MeSH terms

Drug Design*
Enzyme Inhibitors / chemical synthesis
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / pharmacology*
Heterocyclic Compounds, 4 or More Rings / chemical synthesis
Heterocyclic Compounds, 4 or More Rings / chemistry
Heterocyclic Compounds, 4 or More Rings / pharmacology*
Molecular Structure

Substances

Enzyme Inhibitors
Heterocyclic Compounds, 4 or More Rings